An Expeditious Route toward Pyrazine-Containing Nucleoside Analogues

作者：Modha Sachin G; Trivedi Jalpa C; Mehta Vaibhav P; Ermolat'ev Denis S; Van der Eycken Erik V^*

来源：Journal of Organic Chemistry, 2011, 76(3): 846-856.

DOI：10.1021/jo102089h

An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3,5-dichloropyrazin-2(1H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated.

• 出版日期2011-2-4