Nucleating the Assembly of Macromolecular Complexes

作者：Peterson Kaufman Kimberly J; Carlson Clayton D; Rodriguez Martinez Jose A; Ansari Aseem Z^*

来源：ChemBioChem, 2010, 11(14): 1955-1962.

DOI：10.1002/cbic.201000255

• cooperative effects
• molecular recognition
• protein-protein interactions
• scaffold-directed assembly
• synthetic nucleators

Nature constructs intricate complexes containing numerous binding partners in order to direct a variety of cellular processes. Researchers have taken a cue from these events to develop synthetic molecules that can nucleate natural and unnatural interactions for a diverse set of applications. These molecules can be designed to drive protein dimerization or to modulate the interactions between proteins, lipids, DNA, or RNA and thereby alter cellular pathways. A variety of components within the cellular machinery can be recruited with or replaced by synthetic compounds. Directing the formation of multicomponent complexes with new synthetic molecules can allow unprecedented control over the cellular machinery.

• 出版日期2010-9-24