Asymmetric Synthesis of alpha-Amino Acids by Reduction of N-tert-Butanesulfinyl Ketimine Esters

作者:Reddy Leleti Rajender*; Gupta Aditya P; Liu Yugang
来源:Journal of Organic Chemistry, 2011, 76(9): 3409-3415.
DOI:10.1021/jo200401a

摘要

A highly regio- and diastereoselective reduction of various N-tert-butanesulfinyl ketimine esters with L-Selectride resulting in the formation of alpha-amino acids is reported. This method is quite general and also practical for the preparation of both enantiomers of aryl or aliphatic a-amino acids in high yields.

  • 出版日期2011-5-6