Urinary 8-hydroxy-2 %26apos;-deoxyguanosine (8-oxodG) level can predict acute renal damage in young children with urinary tract infection

作者：Chien Jien Wen; Wang Lien Yen; Cheng Yu Shan; Tsai Yi Giien; Liu Chin San^*

来源：Biomarkers, 2014, 19(4): 326-331.

DOI：10.3109/1354750X.2014.910552

• 8-hydroxy-2 %26apos
• -deoxyguanosine
• Tc99m-dimercaptosuccinic acid
• total antioxidant capacity
• urinary tract infection

Background: There are no good biomarkers to predict renal parenchymal involvement in children with urinary tract infection (UTI). %26lt;br%26gt;Methods: Children (N = 73) younger than 5 years with UTI were enrolled. Urinary levels of 8-hydroxy-2%26apos;-deoxyguanosine (8-oxodG) and total antioxidant capacity (TAC) were checked as markers of oxidative stress and antioxidant capacity, respectively. Tc99m-dimercaptosuccinic acid (DMSA) renal scintigraphy was used to find evidence of renal involvement. %26lt;br%26gt;Results: Patients with positive DMSA findings had higher levels of urinary 8-oxodG (p = 0.003) and higher urinary TAC (p = 0.001) than patients with normal DMSA findings. %26lt;br%26gt;Conclusions: High level of urinary 8-oxodG may be a risk factor of severe renal damage.

• 出版日期2014-6
• 单位中国医科大学