US not bright but right method of thyroid volume estimation even in large and substernal extended goitres. Comparison of US and three methods of CT thyroid evaluation - prospective study

作者：Kaniuka Jakubowska Sonia^*; Piskunowicz Maciej; Zapasnik Adam; Lewczuk Anna; Kaniuka Aneta; Mizan Gross Krystyna; Kaszubowski Mariusz; Lass Piotr; Sworczak Krzysztof

来源：Clinical Endocrinology, 2015, 83(3): 412-419.

DOI：10.1111/cen.12629

BackgroundUltrasound is nowadays a method of choice for thyroid volume assessment. However, its disadvantage is some inaccuracy, which is said to be higher in huge, especially substernally extended goitres.
AimsThe aim of the study was to compare the US and CT thyroid volumetric measurements: multi-observers (CT MO) and one-observer (CT OO) to CT planimetry results (CT Pl) in patients with large goitres.
Materials & MethodsThe study material comprised 70 thyroid imaging examinations obtained from 35 patients with nontoxic goitres, scanned twice before and after radioiodine treatment. Mean thyroid volume was 88976021ml. Thirty-three thyroid scans revealed the extension below the jugular notch (mean of 246cm). Thyroid volume in US, CT MO and CT OO was estimated using the ellipsoid formula. CT Pl was established a reference method.
ResultsThe mean thyroid volume in CT Pl was 8897ml (median 8073, range 1181 to 31597). US underestimates thyroid volume by 755ml (77%) with a sufficient correlation (R-2=089) and precision (2037). CT OO is the closest and CT MO the most distant from CT Pl, with US between them in thyroid volume estimation. The percentage US bias is constant through all range of thyroid volume. There is no difference for percentage bias between US and CT Pl for goitres with (867%), and without (670%) substernal part.
ConclusionUS examination is sufficient for epidemiological studies, radioiodine activity calculation and goitre size assessment in everyday medical practice. Neither initial size of the goitre nor its substernal extension affects US assessment precision.

• 出版日期2015-9