Association of BMP-14 rs143383 ploymorphism with its susceptibility to osteoarthritis: A meta-analysis and systematic review according to PRISMA guideline

作者：Yin Yi; Wang Yan^*

来源：Medicine, 2017, 96(42): e7447.

DOI：10.1097/MD.0000000000007447

• BMP-14
• meta-analysis
• osteoarthritis
• polymorphism

Background:Osteoarthritis (OA) is a complex disease which can be caused by both environmental and genetic factors. A functional locus rs143383 of bone morphogenetic protein-14 (BMP-14) has been pointed out to be associated with OA etiology, but conflicting conclusions have been reached. To provide a more comprehensive conclusion about this issue, we performed this meta-analysis.Methods:Relevant studies were searched from electronic databases including PubMed, Chinese National Knowledge Infrastructure, Embase, and Wanfang. The strength of correlations was examined with pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Subgroup analyses stratified by ethnicity and source of control were carried out. All statistical analyses were performed with STATA software (version 12.0).Results:Overall, BMP-14 rs143383 polymorphism was negatively correlated with the susceptibility to knee OA and hand OA under genetic contrasts of CC versus TT, CC+TC versus TT, CC versus TT+TC, C versus T, TC versus TT (OR=0.71, 95% CI=0.65-0.79; OR=0.81, 95% CI=0.73-0.89; OR=0.79, 95% CI=0.71-0.86; OR=0.85, 95% CI=0.81-0.90; OR=0.84, 95% CI=0.75-0.93), and TC versus TT, CC versus TT+TC, C versus T (OR=0.76, 95% CI=0.65-0.89; OR=0.79, 95% CI=0.68-0.92; OR=0.90, 95% CI=0.85-0.95), respectively; similar results were observed in subgroups after stratification analyses. Additionally, the polymorphism also reduced hip OA risk in Asian group after stratified analysis by ethnicity.Conclusion:BMP-14 rs143383 polymorphism may be a protective factor against OA occurrence.

• 出版日期2017-10
• 单位中国人民解放军总医院