A Review of the Chemical and Pharmacological Aspects of the Genus Marrubium

作者：Meyre Silva Christiane^*; Cechinel Filho Valdir

来源：Current Pharmaceutical Design, 2010, 16(31): 3503-3518.

DOI：10.2174/138161210793563392

• Marrubium
• ethnopharmacology
• chemical composition
• M. vulgare
• labdane terpenes
• essential oils
• analgesic and anti-inflammatory effects
• antimicrobial

The genus Marrubium (Lamiaceae) is comprised of about forty species, distributed in Europe, Asia and Brazil. Some species are traditionally used to treat various diseases, including asthma, pulmonary infections, inflammation and hypotension, as cholagogues and sedative agents, and for pain relief. A literature review on the chemical and biological aspects of these plants indicates antimicrobial activity against gram positive bacteria, analgesic properties, and anti-hypertensive, antidiabetic, antioxidant properties, among others, particularly related to the presence of diterpenes, sterols, phenylpropanoids and flavonoids. This review shows the main chemical and pharmacological aspects of the genus Marrubium, with emphasis on M. vulgare, which grows in Brazil and has been studied by us and other authors.

• 出版日期2010