An efficient one-pot synthesis of thiophene-fused pyrido[3,2-a]azulenes via Gewald reaction

作者：Wang, Dao-Lin^*; Wu, Jian-Ying; Cui, Qing-Tao

来源：Chinese Chemical Letters, 2014, 25(12): 1591-1594.

DOI：10.1016/j.cclet.2014.07.007

• Azulene
• Thiophene
• Pyridinone
• Gewald reaction

A simple and efficient procedure was developed for the synthesis of 11H(2H)-4-oxothiophene[3',4':6,5]pyrido[3,2-a]azulene-10-carboxylates (3) in moderate to good yields via the Gewald reaction of ethyl 1-cyanoacety1-2-methoxyazulene-3-carboxylate (1) with carbonyl compounds (2) and elemental sulfur utilizing imidazole as catalyst. This reaction provides a new procedure for synthesis of pyridinone-fused azulenes.

• 出版日期2014-12
• 单位渤海大学