Novel inhibitors of Mycobacterium tuberculosis growth based on modified pyrimidine nucleosides and their analogues

作者:Shmalenyuk E R*; Kochetkov S N; Alexandrova L A
来源:Russian Chemical Reviews, 2013, 82(9): 896-915.
DOI:10.1070/RC2013v082n09ABEH004404

摘要

The review summarizes data on the synthesis and antituberculosis activity of pyrimidine nucleoside derivatives and their analogues. Enzymes from M. tuberculosis as promising targets for prototypes of new-generation drugs are considered. Nucleosides as inhibitors of drug-resistant M. tuberculosis strains are characterized. The bibliography includes 101 references.

  • 出版日期2013