Adhesio interthalamica alterations in schizophrenia spectrum disorders: A systematic review and meta-analysis

作者：Trzesniak Clarissa^*; Kempton Matthew J; Busatto Geraldo F; de Oliveira Irismar Reis; Galvao de Almeida Amanda; Kambeitz Joseph; Freitas Ferrari Maria Cecilia; Santos Filho Alaor; Chagas Marcos H N; Zuardi Antonio W; Hallak Jaime E C; McGuire Phillip K; Crippa Jose Alexandre S

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2011, 35(4): 877-886.

DOI：10.1016/j.pnpbp.2010.12.024

• Adhesio interthalamica
• Magnetic resonance imaging
• Massa intermedia
• Meta-analysis
• Schizophrenia
• Thalamus

Magnetic resonance imaging (MRI) studies have reported a variety of brain abnormalities in association with schizophrenia. These include a higher prevalence of an absent adhesio interthalamica (Al; also known massa intermedia), a gray matter junction that is present between the two thalami in approximately 80% of healthy subjects. In this meta-analytic review, we describe and discuss the main Al MRI findings in schizophrenia spectrum disorders (SSDs) to date. The MEDLINE and ISI Web of Knowledge(SM) databases were searched up to December 2010, for studies that used MRI to assess Al in patients with SSD and controls. From fourteen potential reports, eleven were eligible to be part of the current review. These studies included 822 patients with SSD and 718 healthy volunteers. There was a large degree of variability in the MRI methods they employed. Patients with SSD had a higher prevalence of absent Al than healthy volunteers (odds ratio = 1.98; 95% confidence interval 1.33-2.94: p=0.0008). This association was evident in both male and female SSD subjects, and there was no evidence that the prevalence was related to age or duration of illness. The significance of the absence of an Al for SSD may be clarified by studies in large, longitudinal community-based samples using standardized methods.

• 出版日期2011-6-1