A biocompatible composite based on poly(epsilon-caprolactone fumarate) and hydroxyapatite

作者：Shafieyan Yousef; Sharifi Shahriar; Imani Mohammad^*; Shokrgozar Mohammad Ali; Aboudzadeh Neda; Atai Mohammad

来源：Polymers for Advanced Technologies, 2011, 22(12): 2182-2190.

DOI：10.1002/pat.1743

• polymer-matrix composites (PMCs)
• hydroxyapatite
• mechanical properties
• electron microscopy
• biocompatibility

Fabrication of biodegradable composites applicable as hard tissue substitutes consisting of poly(epsilon-caprolactone fumarate) (PCLF), methacrylic acid (MAA), and hydroxyapatite (HA) was investigated. PCLF macromers were synthesized by reaction of PCL diol with fumaryl chloride in the presence of propylene oxide and characterized by gel permeation chromatography, FTIR, and (1)H NMR spectroscopy. Composites were fabricated by incorporating HA as inorganic filler in PCLF matrix which followed by thermal curing of the composition using benzoyl peroxide and MAA as a free radical initiator and reactive diluent, respectively. Uniform distribution of the fine ceramic phase in the polymer matrix was elucidated by scanning electron microscopy. The effects of the initial macromer molecular weight and the filler volume fraction on mechanical properties and cytotoxicity of the composites were also examined. Significant enhancement in the mechanical properties was observed upon increasing HA content and/or initial PCLF molecular weight. The biocompatibility of the specimens was also improved with increasing ceramic phase.

• 出版日期2011-12