Astragaloside Improves Outcomes of Traumatic Brain Injury in Rats by Reducing Microglia Activation

作者：Yang Shun Tai; Lin Jia Wei; Chiu Bi Ying; Hsu Yao Chin; Chang Ching Ping^*; Chang Cheng Kuei

来源：American Journal of Chinese Medicine, 2014, 42(6): 1357-1370.

DOI：10.1142/S0192415X14500852

• Traumatic Brain Injury
• Astragaloside
• Tumor Necrosis Factor-Alpha
• Microglia

Astragaloside (AST) is traditionally prescribed for the prevention and treatment of cerebrovascular diseases. We directly tested the therapeutic effects of AST in a rat model of traumatic brain injury (TBI). One hour after the onset of TBI rats were given Saline (1 ml/kg) or AST (20-80 mg/kg) via i.p. injection. AST causes the attenuation of TBI-induced cerebral contusion, neuronal apoptosis, and neurological motor dysfunction. TBI-induced microglial activation evidenced by the morphological transformation of microglia (or ameboid microglia) and the microglial overexpression of tumor necrosis factor-alpha was reduced by AST. Our results indicate that AST may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats.

• 出版日期2014