Usefulness of H-1 magnetic resonance spectroscopy in human testes: preliminary study

作者：Baleato Gonzalez S^*; Garcia Figueiras R; Santiago Perez M I; Requejo Isidro I; Vilanova J C

来源：Clinical Radiology, 2015, 70(9): 1026-1031.

DOI：10.1016/j.crad.2015.05.010

AIM: To identify and quantify the metabolites detected on proton magnetic resonance spectroscopy (H-1-MRS) in human testes.
MATERIALS AND METHODS: The institutional review board approved the study, and all patients provided informed consent. A total of 27 patients consulting the Urology Department underwent single-voxel H-1-MRS (4000 ms repetition time [RT], 31 ms echo time [TE], 128 averages for each TE) at 1.5 T. Spectroscopy was not evaluable in one patient, and four patients had only one testis; thus, 48 testes were studied. Choline-containing compounds (Cho) and methylene lipid (Lip) values were measured and the Cho/Lip ratio was calculated. Testes were classified as normal or abnormal based on conventional magnetic resonance imaging (MRI) findings. The ManneWhitney U-test was used for correlated data and bootstrapping to compare mean Cho/Lip ratios between normal and abnormal testes, and the area under the receiver operating characteristic curve (AUC) was calculated.
RESULTS: Thirty testes were classified as normal and 18 as abnormal. The mean Cho/Lip ratio was 1.02 +/- 0.46 in normal testes and 0.45 +/- 0.36 in abnormal testes (Mann-Whitney U, p=0.001; bootstrapping mean difference, 0.57; 95% confidence interval (CI) 0.32-0.82; AUC=0.833).
CONCLUSION: H-1-MRS could be useful in routine clinical practice to identify the major metabolites in the testes and help discriminate between normal and abnormal testes.

• 出版日期2015-9