No significant effect of orally administered chemokine receptor 1 antagonist on intercellular adhesion molecule-3 expression in relapsing-remitting multiple sclerosis patients

作者：Reuss R^*; Schreiber V; Klein A; Infante Duarte C; Filippi M; Pabst W; Pohl C; Oschmann P

来源：Multiple Sclerosis, 2010, 16(3): 366-369.

DOI：10.1177/1352458509358188

• chemokine receptor 1 antagonist
• flow cytometry
• intercellular adhesion molecule-3
• MRI
• multiple sclerosis
• receptor cross-talk

We investigated the expression of intercellular adhesion molecules ICAM-1 and ICAM-3 on peripheral blood mononuclear cells in a subgroup of 34 patients with relapsing-remitting multiple sclerosis who were treated orally with the chemokine receptor 1 antagonist BX 471 in a 16-week, randomised, double-blind, placebo-controlled phase II study. ICAM-1 and ICAM-3 expression was measured by flow cytometry at different time points during and after therapy and compared using multivariate analysis of variance and non-parametric Mann Whitney test. ICAM-3 expression on CD14 (+) peripheral blood mononuclear cells was increased in the verum group under therapy, but did not differ significantly between the verum and placebo groups. Most likely, this trend represents a small epiphenomenon only mediated by receptor cross-talk and feedback mechanisms.

• 出版日期2010-3
• 单位河北医科大学