Melanocytes are more responsive to IFN-gamma and produce higher amounts of kynurenine than melanoma cells

作者：Clara Renan Orsati^*; Assmann Nadine; Ramos Moreno Ana Carolina; Coimbra Janine Baptista; Nurenberger Nadine; Dettmer Wilde Katja; Oefner Peter Josef; Campa Ana

来源：Biological Chemistry, 2016, 397(1): 85-90.

DOI：10.1515/hsz-2015-0173

• interferon-gamma
• melanocytes
• melanoma
• metabolism
• tryptophan

A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-gamma plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to IFN-gamma. In general, IFN-gamma affected KP in skin cells more than in melanoma cells, supporting IFN-gamma roles in skin physiology and that of stromal cells in modulating the tumor microenvironment.

• 出版日期2016-1