Anti-HBV constituents from Euphorbia fischeriana

作者：Yu M; Hou A^*

来源：China Journal of Chinese Materia Medica, 2010, 35(22): 3002-3006.

DOI：10.4268/cjcmm20102215

• Anti-HBV activity
• Coumarins
• Euphorbia fischeriana
• Tannins
• Terpenoids

Objective: To investigate the anti-HBV constituents in the roots of Euphorbia fischeriana. Method: The compounds were isolated by various chromatographic methods and identified by spectroscopic analysis. Some compounds were tested for the anti-HBV activity. Result: Eleven compounds were isolated and identified as tirucalla-5, 24-dien-3-ol (1), 24-methyltirucalla-5, 24-dien-3-ol (2), euphol (3), butyrospermol (4), 24-methylenecycloartenol (5), cycloartenol (6), jolkinolid E (7), helioscopinolide A (8), isoscopoletion (9), dephnoretin (10), and 3, 3′-di-O-methylellagic acid 4′-O-β-D- xylopyranoside (11). Conclusion: Compounds 1, 2 and 10 were isolated from the genus Euphorbia for the first time. Compounds 3, 4 and 11 were isolated from this species for the first time. Compounds 1, 8, 9 and 11 showed weak anti-HBsAg and anti-HBeAg activity, while compound 10 showed weak anti-HBsAg activity.

• 出版日期2010
• 单位复旦大学