Association study between MAO-A gene promoter VNTR polymorphisms and obsessive-compulsive disorder

作者：Liu, Shiguo; Yin, Yingying; Wang, Zusen; Zhang, Xinhua^*; Ma, Xu

来源：Journal of Anxiety Disorders, 2013, 27(4): 435-437.

DOI：10.1016/j.janxdis.2013.04.005

• Mono-amine oxidase-A gene (MAO-A)
• Variable number of tandem repeats (VNTR)
• Polymorphism
• Obsessive-compulsive disorder (OCD)

A functional variant in the mono-amine oxidase-A (MAO-A) gene has been shown to affect neural function related to several mental disorders. Therefore, we would like to ascertain if MAO-A could be a candidate gene for obsessive-compulsive disorder (OCD). We genotyped 414 healthy subjects and 240 OCD patients and found no significant difference not only in allele frequencies in male patients (chi(2)=0.365, DF=1, P=0.545, odds ratio (OR)=1.139, confidence interval (CI)=0.75-1.74) but also in allele frequencies (chi(2)=0.698, DF=1, P=0.404, OR=0.849, CI=0.579-1.246) or genotypic frequencies (chi(2)=0.933, DF=2, P=0.627) in female patients between OCD patients and controls. Given that this is the first investigation of this gene in OCD in a Chinese Han population, further studies are required to obtain more definitive conclusions in a larger number of subjects.

• 出版日期2013-5
• 单位青岛大学; 国家卫生计生委科学技术研究所; 中国医学科学院北京协和医院