科研之友
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摘要
The present study was aimed at evaluating analgesic and antiulcer activities of the ethanolic (BVE) and aqueous (BVA) extracts of root of Bauhinia variegata Linn., respectively in animal models. The analgesic activity was evaluated for its central and peripheral pharmacological actions by using Eddy's hot plate method and acetic acid-induced writhing, respectively. The anti-ulcer activity was evaluated by using pylorus ligation, ethanol and aspirin induced ulcer models. The study was carried out in two different dose levels of 200 and 400 mg kg(-1) body weight orally for both ethanolic and aqueous extracts, respectively. BVE and BVA did not produce any mortality up to 2000 mg kg(-1). Dose dependent increase in latency of response in the hot plate method was observed with BVE 400 mg kg(-1) and 81% inhibition in acetic acid induced writhings in mice was observed with BVA 400 mg kg(-1). BVE and BVA at both the doses showed 99% protection in ethanol induced ulcer model. BVE 400 mg kg(-1) showed 99.9% protection in aspirin induced ulcer model. Both BVE and BVA at the dose of 400 mg kg(-1) showed 99.8% protection in pylorus ligation ulcer model. Pharmacological screening of the root extracts of Bauhinia variegata Linn. showed significant (p<0.001) dose dependent analgesic activity and significant (p<0.001) anti-ulcer activity when compared with reference standard. Presence of flavonoids might be responsible for these activities. NSAIDs are associated with side effects of gastric ulcers. BVE and BVA are reported to be plant-derived natural remedy having analgesic and anti-ulcer activities.
- 出版日期2011-7-1
