Mast Cell-Mediated Mechanisms of Nociception

作者：Aich Anupam; Afrin Lawrence B; Gupta Kalpna

来源：International Journal of Molecular Sciences, 2015, 16(12): 29069-29092.

DOI：10.3390/ijms161226151

• mast cells
• pain
• migraine
• cytokines
• cancer
• inflammation
• substance P
• tryptase
• hyperalgesia
• sickle cell disease

Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-attractants, vasoactive compounds, neuropeptides and growth factors in response to allergens and pathogens constituting a first line of host defense. The neuroimmune interface of immune cells modulating synaptic responses has been of increasing interest, and mast cells have been proposed as key players in orchestrating inflammation-associated pain pathobiology due to their proximity to both vasculature and nerve fibers. Molecular underpinnings of mast cell-mediated pain can be disease-specific. Understanding such mechanisms is critical for developing disease-specific targeted therapeutics to improve analgesic outcomes. We review molecular mechanisms that may contribute to nociception in a disease-specific manner.

• 出版日期2015-12