Antigen delivery systems for veterinary vaccine development Viral-vector based delivery systems

作者：Brun Alejandro^*; Albina Emmanuel; Barret Tom; Chapman David A G; Czub Markus; Dixon Linda K; Keil Guenther M; Klonjkowski Bernard; Le Potier Marie Frederique; Libeau Genevieve; Ortego Javier; Richardson Jennifer; Takamatsu Haru H

来源：Vaccine, 2008, 26(51): 6508-6528.

DOI：10.1016/j.vaccine.2008.09.044

• Antigen delivery systems
• Veterinary vaccines
• Modified live virus
• Viral vectors
• Poxvirus vectors
• Herpesvirus vectors
• Adenovirus vectors
• Baculovirus vectors
• Positive strand RNA virus vectors
• Negative strand RNA virus vectors

The recent advances in molecular genetics, pathogenesis and immunology have provided an optimal framework for developing novel approaches in the rational design of vaccines effective against viral epizootic diseases. This paper reviews most of the viral-vector based antigen delivery systems(ADSs) recently developed for vaccine testing in veterinary species, including attenuated virus and DNA and RNA viral vectors. Besides their usefulness in vaccinology, these ADSs constitute invaluable tools to researchers for understanding the nature Of protective responses in different species, opening the possibility of modulating or potentiating relevant immune mechanisms involved in protection.

• 出版日期2008-12-2