A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale

作者：Zhang, Shixiong; Deng, Ping; Zhou, Jing; Liu, Mouxiong; Liang, Guojuan; Xiong, Yan; Zhou, Hui^*

来源：Chemical Communications, 2017, 53(96): 12914-12917.

DOI：10.1039/c7cc06468c

• BETA-KETO-ESTERS
• BASE COMPLEX
• ALLIBIS(BINAPHTHOXIDE) COMPLEX
• ENANTIOSELECTIVE SYNTHESIS
• BIFUNCTIONAL CATALYSIS
• SYNTHETIC APPLICATIONS
• CINCHONA ALKALOIDS
• UNMODIFIED KETONES
• CHIRAL AZIRIDINES
• AMINO ALCOHOLS

A novel dinuclear Ni complex has been developed for the direct Mannich reaction of malonates with N-tosyl aryl imines with a low catalyst loading (0.1-0.05 mol%) on a preparative scale (5-50 mmol). The structure of the active species was verified via control experiments, ESI-HRMS, and DFT calculations.

• 出版日期2017-12-14
• 单位重庆大学; 重庆医科大学