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摘要
We demonstrate control over the morphology and shape of microparticles. Two different types of microparticles (core-shell or acorn shaped) were produced by the varying the blend ratio of two immiscible biodegradable polymers in a tube-type microfluidic device. Subsequent use of selective solvent extraction resulted in the formation of hollow-core, crescent-shaped and dimple surfaced microparticles. A selective solvent, tetraglycol, which has been applied for intravenous injection in the human body, is used instead of organic solvents which can be toxic if remaining in microparticles.
- 出版日期2014
