Asymmetric Synthesis of Substituted Thiolanes through Domino Thia-Michael-Henry Dynamic Covalent Systemic Resolution using Lipase Catalysis

作者：Zhang Yan; Vongvilai Pornrapee; Sakulsombat Morakot; Fischer Andreas; Ramstrom Olof^*

来源：Advanced Synthesis & Catalysis, 2014, 356(5): 987-992.

DOI：10.1002/adsc.201301033

• adaptive features
• biotransformations
• chiral resolution
• domino reactions
• dynamic chemistry
• enzymes
• lipase
• stereochemistry

Dynamic systems based on consecutive thia-Michael and Henry reactions were generated and transformed using lipase-catalyzed asymmetric transformation. Substituted thiolane structures with three contiguous stereocenters were resolved in the process in high yields and high enantiomeric excesses.

• 出版日期2014-3-24