Anatomical distribution analysis reveals lack of Langerin plus dermal dendritic cells in footpads and tail of C57BL/6 mice

作者：Voisin Benjamin; Mairhofer David Gabriel; Chen Suzie; Stoitzner Patrizia; Mueller Christopher George; Flacher Vincent^*

来源：Experimental Dermatology, 2014, 23(5): 354-357.

DOI：10.1111/exd.12373

• dermal dendritic cells
• footpad skin
• Langerhans cells
• skin-draining lymph nodes
• tail skin

Epidermal Langerhans cells (LCs) and dermal dendritic cells (dDCs) capture cutaneous antigens and present them to T-cells in lymph nodes (LNs). The function of LCs and Langerin+ dDCs was extensively studied in the mouse, but their anatomical repartition is unknown. Here, we found LCs in back skin, footpads and tail skin of C57BL/6, BALB/c, 129/Sv and CBA/J mice. Langerin+ dDCs were readily observed in back skin of all strains, but only in footpads and tail of BALB/c and CBA/J mice. Similarly, while LCs were equally present in all LNs and strains, Langerin+ dDCs were found in popliteal LNs (draining footpads) only in BALB/c and CBA/J mice. The sciatic LNs, which we identified as the major tail-draining lymphoid organ, were devoid of Langerin+ dDCs in all strains. Thus, functionally different DCs reside in different skin areas, with variations among mouse strains, implying a potential impact on the cutaneous immune reaction.

• 出版日期2014-5