A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

作者：Li, Wenjun; Wang, Dongyuan; Shi, Xiaodong; Li, Jingxu; Ma, Yue; Wang, Yanding; Li, Tingting; Zhang, Jianing; Zhao, Rongtong; Yu, Zhiqiang; Yin, Feng^*; Li, Zigang^*

来源：Materials Horizons, 2018, 5(4): 745-752.

DOI：10.1039/c8mh00392k

• CELL-PENETRATING PEPTIDES
• PROTEIN-PROTEIN INTERACTIONS
• ALPHA-HELICAL PEPTIDES
• TARGETED DRUG-DELIVERY
• IN-VIVO DELIVERY
• UNPROTECTED PEPTIDES
• STAPLED PEPTIDES
• NONVIRAL VECTORS
• RNA INTERFERENCE
• MAMMALIAN-CELLS

Herein, we report a unique siRNA-induced peptide co-assembly nanocarrier, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo. In a tumor xenograft nude mouse model, these siRNA-peptide nanospheres inhibited tumor volume growth by 460%.

• 出版日期2018-7-1
• 单位南方医科大学; 北京大学深圳研究生院