A personalized view on cancer immunotherapy

作者：Wayteck Laura; Breckpot Karine; Demeester Jo; De Smedt Stefaan C; Raemdonck Koen^*

来源：Cancer Letters, 2014, 352(1): 113-125.

DOI：10.1016/j.canlet.2013.09.016

• Cancer immunotherapy
• Personalized medicine
• Tumor antigens
• Predictive biomarkers
• Tumor heterogeneity
• Adoptive T cell therapy

Recent progress in cancer immunotherapy has resulted in complete responses in patients refractory to current standard cancer therapies. However, due to tumor heterogeneity and inter-individual variations in anti-tumor immunity, only subsets of patients experience clinical benefit. This review highlights the implementation of a personalized approach to enhance treatment efficacy and reduce side effects, including the identification of tumor-specific antigens for cancer vaccination and adoptive T cell therapies. Furthermore, together with the current advances and promising clinical outcomes of combination cancer (immuno-)therapies, the screening for predictive biomarkers in a patient-specific manner is emphasized.

• 出版日期2014-9-28