N,N '-Dioxide-Scandium(III)-Catalyzed Asymmetric Michael Addition of beta,gamma-Unsaturated Butenolides to alpha,beta-Unsaturated gamma-Keto Esters

作者：Ji Jie; Lin Lili; Zhou Lin; Zhang Yuheng; Liu Yangbin; Liu Xiaohua; Feng Xiaoming^*

来源：Advanced Synthesis & Catalysis, 2013, 355(14-15): 2764-2768.

DOI：10.1002/adsc.201300586

• asymmetric catalysis
• gamma-butenolides
• N,N '-dioxides
• Michael addition
• scandium

A highly efficient N,N-dioxide-scandium(III) complex catalytic system has been developed for the asymmetric vinylogous Michael reaction of -angelica lactone and its derivatives to ,-unsaturated -keto esters, affording the corresponding ,-disubstituted butenolide products in moderate to good yields (up to 93%) with high dr (up to >19:1) and ee values (up to 97%) under mild reaction conditions.

• 出版日期2013-10-11
• 单位四川大学