Molecular features and clinical outcome of lung malignancies in very young people

作者：Catania Chiara^*; Botteri Edoardo; Barberis Massimo; Conforti Fabio; Toffalorio Francesca; De Marinis Filippo; Boselli Sabrina; Noberasco Cristina; Delmonte Angelo; Spitaleri Gianluca; Spaggiari Lorenzo; Rotmensz Nicole; Passaro Antonio; Bazolli Barbara; Alfieri Marina; Manzotti Michela; Fumagalli Caterina; Milani Alessandra; De Pas Tommaso

来源：Future Oncology, 2015, 11(8): 1211-1221.

DOI：10.2217/fon.15.10

• carcinoid
• lung cancer
• molecular features
• neuroendocrine
• young patients

Introduction: We describe the clinical features, outcome and incidence of druggable targets of lung cancers in patients 40 years old. Materials & methods: Young patients were compared with two other groups (41-64 and 65 years). Neuroendocrine tumors, adenocarcinoma and non-adenocarcinoma/unspecified non-small-cell lung cancer were analyzed separately. Molecular characteristics of adenocarcinoma were evaluated in a subset of young patients. Results: Of 2847 patients with lung cancer, 100 were 40 years old. The young group contained more women, never-smokers and patients presenting with advanced disease. The commonest tumor in young patients was adenocarcinoma. In total, 19 of 34 young patients with adenocarcinoma had tumors with specific molecular alterations. Conclusion: Lung cancers in young patients have distinctive features but outcomes similar to those in older patients.

• 出版日期2015