Discovery of anticancer agents of diverse natural origin

Kinghorn A Douglas<sup>*</sup>; de Blanco Esperanza J Carcache; Chail Hee Byung; Orjala Jimmy; Farnsworth Norman R; Soejarto D Doel; Oberlies Nicholas H; Wani Mansukh C; Kroll David J; Pearce Cedric J; Swanson Steven M; Kramer Robert A; Rose William C; Fairchild Craig R; Vite Gregory D; Emanuel Stuart; Jarjoura David; Cope Frederick O

doi:10.1351/PAC-CON-08-10-16

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Discovery of anticancer agents of diverse natural origin

作者：Kinghorn A Douglas^*; de Blanco Esperanza J Carcache; Chail Hee Byung; Orjala Jimmy; Farnsworth Norman R; Soejarto D Doel; Oberlies Nicholas H; Wani Mansukh C; Kroll David J; Pearce Cedric J; Swanson Steven M; Kramer Robert A; Rose William C; Fairchild Craig R; Vite Gregory D; Emanuel Stuart; Jarjoura David; Cope Frederick O

来源：Pure and Applied Chemistry, 2009, 81(6): 1051-1063.

DOI：10.1351/PAC-CON-08-10-16

摘要

A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which crude extracts of these acquisitions are tested. Progress made in the isolation of lead bioactive secondary metabolites from three tropical plants is discussed.