An association model for the solubilities of pharmaceuticals in supercritical carbon dioxide

作者：Ch Rajasekhar; Madras Giridhar^*

来源：Thermochimica Acta, 2010, 507-08: 99-105.

DOI：10.1016/j.tca.2010.05.006

• Solubilities
• Association model
• Isopropylantipyrine
• Drugs
• Supercritical fluids

The equilibrium solubility of a pharmaceutical compound. 1,5-dimethy1-2-phenyl-4-propan-2-ylpyrazol-3-one (propyphenazone, isopropylantipyrine) in supercritical carbon dioxide (SCCO(2)) was experimentally determined by a saturation method at 308, 318 and 328 K. over the pressure range of 9.0-19.0 MPa. The solubility data satisfied the self-consistency test, proposed by Mendez-Santiago and Teja. A new association model was derived to correlate the solubilities of pharmaceutical compounds in SCCO(2). Solubility data from 54 different pharmaceutical compounds including steroids, antibiotics, anti-inflammatory, antioxidants, statins and specific functional drugs were collected from literature. The model successfully correlated the experimental results for the solubilities of all these compounds in SCCO(2) within 12% AARD.

• 出版日期2010-8-10