Association between the interleukin-1 alpha gene and Alzheimer's disease: a meta-analysis

作者：Rainero I^*; Bo M; Ferrero M; Valfre W; Vaula G; Pinessi L

来源：Neurobiology of Aging, 2004, 25(10): 1293-1298.

DOI：10.1016/j.neurobiolaging.2004.02.011

• Alzheimer's disease
• interleukin-1 genes
• polymorphism
• meta-analysis

Inflammatory processes are involved in the pathogenesis of Azheimer's disease (AD). Several studies have addressed the effects of interleukin-1 (IL-1) genes polymorphisms on the risk of developing AD. The results are not in full agreement on whether these polymorphisms are associated with the disease. To clarify this issue, we performed a meta-analysis of all the association studies between IL-1 genes and AD. Due to the relatively small number of published articles, the meta-analysis was restricted to the association of the IL-1alpha -889 C/T gene polymorphism and AD. Under a random effects model, the risk for the disease was significantly higher in subjects with the T/T genotype in comparison with both C/T (OR: 1.51; 95% C.I.: 1.15-1.99) and C/C (OR: 1.49; 95% C.I.: 1.09-2.03) subjects. There was modest heterogeneity for these effect estimates. Analysis of subgroups showed a significant association in patients with early-onset AD but not in late-onset AD. Our data support a significant but modest association between the T/T genotype of the IL-1alpha gene and AD.

• 出版日期2004-12