An efficient synthesis of novel dihydrothiazol-2-yl-amides via cyclisation of propargylic carbamothioyl-amides

作者:Saeedi Mina; Goli Fereshteh; Mahdavi Mohammad; Sarihi Pouria; Asadipour Ali; Shafiee Abbas; Foroumadi Alireza*
来源:Journal of Chemical Research, 2014, 38(3): 131-133.
DOI:10.3184/174751914X13899480812215

摘要

An efficient protocol is described for the versatile synthesis of novel dihydrothiazol-2-yl-amide derivatives via the regioselective 5-exo-dig heterocyclisation of N-propargyl carbamothioyl-amides in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) in refluxing ethanol. All products were obtained in good yields and short reaction time (10-30 min).

  • 出版日期2014-3