The non-agouti mutation in Norway rats (Rattus norvegicus) selected for behavior

作者：Gulevich R^*; Oskina I; Ilyina O; Herbeck Yu; Plyusnina I; Trut L

来源：Canadian Journal of Zoology, 2013, 91(3): 111-117.

DOI：10.1139/cjz-2012-0008

• Norway rats
• Rattus norvegicus
• non-agouti mutation
• selection for behavior
• mother
• offspring
• transmission distortion

The frequency of aa homozygous descendants was studied in crosses of Aa heterozygous Norway rat (Rattus norvegicus (Berkenhout, 1769)) parents selected for tame and aggressive behavior. First, Aa heterozygotes were obtained in crosses between tame homozygotes for the wild-type allele (AA) and aggressive homozygotes for the non-agouti allele (aa). The most tame and the most aggressive descendants were selected from the progeny of the Aa genotype by using the glove test. Then Aa rats were crossed among tame and among aggressive descendants, and the AA and Aa genotypes of grey descendants were identified by polymerase chain reactions (PCR). The segregation of descendants into the AA, Aa, and aa genotypes was cumulatively analyzed in five generations of selection with regard to the phenotypic manifestation of tame and aggressive behavior in their parents. The frequency of aa descendants in the progeny of mothers with low aggressive behavior scores was less than expected and less than in the progeny of mothers with high aggressive behavior scores.

• 出版日期2013-3