Aberrant Expression of Vimentin Correlates with Dedifferentiation and Poor Prognosis in Patients with Intrahepatic Cholangiocarcinoma

作者：Korita Pavel V; Wakai Toshifumi; Ajioka Yoichi^*; Inoue Makoto; Takamura Masaaki; Shirai Yoshio; Hatakeyama Katsuyoshi

来源：Anticancer Research, 2010, 30(6): 2279-2285.

• Intrahepatic cholangiocarcinoma
• vimentin
• surgical resection
• prognosis

Background: This study aimed to elucidate the prognostic value of vimentin expression in patients with intrahepatic cholangiocarcinoma (ICC). Patients and Methods: A retrospective analysis of 21 patients who underwent resection for ICC was conducted. Vimentin expression was positive when single tumour cells or cell clusters showed immunoreactivity to vimentin, whereas vimentin-negative expression was defined as no detectable expression. Results: Of the 21 patients, 5 were classified as having tumours with vimentin-positive expression and 16 with vimentin-negative expression. Vimentin-positive expression was more frequent in tumour specimens that were poorly differentiated (417; 57%) than in those that were well- or moderately differentiated (1114; 7%, p=0.025) and was always seen in areas with the highest histological grade. Vimentin-positive expression affected survival adversely, according to univariate (p=0.010) and multivariate analyses (relative risk, 4.294; p=0.047). Conclusion: Vimentin-positive expression correlates with dedifferentiation and predicts poor survival in patients undergoing resection for ICC.

• 出版日期2010-6