USEFULNESS OF ROSEN'S POSTULATE FOR STUDYING THE RELATIONSHIP BETWEEN THE STRUCTURE OF CHOLIC ACID OXYETHYLATION PRODUCTS AND THE PROCESS OF SOLUBILIZATION OF LIPOPHILIC THERAPEUTIC AGENTS (BCS CLASS II AND IV) IN AQUEOUS SOLUTIONS IN EQUILIBRIUM

作者：Nachajski Michal Jakub^*; Kolodziejczyk Michal Krzysztof; Lukosek Marek; Kosno Jacek; Kolodziejska Justyna; Zgoda Marian Mikolaj

来源：Acta Poloniae Pharmaceutica, 2014, 71(4): 637-645.

• oxyethylation
• cholic acid
• oxyethylates of cholic acid
• surfactants
• Rosen's postulate

We verified the usefulness of "Rosen's postulate", i.e., the logarithm of reciprocal concentration of surfactant -log(1/c(pi=20)) by which the surface tension of a solution can be decreased by 20 mJ/m(2) in relation to water (physiological value gamma(25) = 48-52 mJ/m(2)) in the evaluation of the applicatory properties of cholic acid oxyethylation products. Moreover, the values of Delta G(m)(0) for solubilizers and their micellar adducts with diclofenac, naproxen, and loratadine constituted the basis for estimating the thermodynamic value of "Rebinder's effect", associated with change in the state of matter of therapeutic agent. We determined critical micellar concentration for the aqueous products of oxyethylation and for micellar adducts with diclofenac, naproxen, and loratadine, and used these values to calculate (thermodynamic potential of micelle formation).

• 出版日期2014-8