科研之友
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摘要
The effects of La3+ on proliferation, cell cycles, apoptosis and ion channels were investigated in mouse embryo fibroblast NIH 3T3 cells and its possible mechanisms were explored. Our data showed that La3+ promoted cell proliferation with increased S-phase entry and inhibited the outward potassium currents in a concentration-dependent manner in NIH 3T3 cells. La3+ and Ca2+ had synergistic effect on cell proliferation and cell cycles. It showed that Ca2+ was needed for La3+-promoted cell cycle progression. Using the whole-cell voltage-clamp technique, we found that La3+ blocked the outward potassium current in a concentration-dependent manner in NIH 3T3 cells. Lanthanum ions can increase intracellular Ca2+ concentration through inhibition of potassium currents, which induce a series of physiological changes and improve proliferation of cells. This may be one of the molecular mechanisms of lanthanum ions induced cell proliferation. The present work provides a new perspective for understanding the biological and toxicological effects of lanthanum.
