Acquisition of anoikis resistance reveals a synoikis-like survival style in BEL7402 hepatoma cells

作者：Zhang, Zhiyong; Cao, Lill; Li, Jie; Liang, Xiaohong; Liu, Yugang; Liu, Hua; Du, Juan; Qu, Zhonghua; Cui, Min; Liu, Suxia; Gao, Lifen; Ma, Chunhong; Zhang, Lining; Han, Lihui^*; Sun, Wensheng

来源：Cancer Letters, 2008, 267(1): 106-115.

DOI：10.1016/j.canlet.2008.03.010

• hepatoma
• apoptosis
• anoikis
• synoikis-like
• ANGPTL4

Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and proliferate again under suitable conditions, which indicate a reversible property of these cells. Microarray expression profile reveals the change of molecules involved in the synoikis-like hepatoma cells and our data indicated that ANGPTL4 contributed to anoikis resistance of hepatoma cells. These results demonstrated that hepatoma cells might resist anoikis through a synoikis-like survival style, which may facilitate tumor metastasis.

• 出版日期2008-8-18
• 单位山东大学; 山东省千佛山医院