Atomic force microscopy as a tool for biomedical and biotechnological studies

作者：Cidade GAG^*; Costa LT; Weissmuller G; Neto AJD; Roberty NC; de Moraes MB; Prazeres GMP; Hill CEM; Ribeiro SJM; de Souza GGB; Teixeira LDP; Moncores MD; Bisch PM

来源：Artificial Organs, 2003, 27(5): 447-451.

DOI：10.1046/j.1525-1594.2003.07237.x

• atomic force microscopy
• image restoration
• force spectroscopy
• biological samples
• tip functionalization

This work presents different applications in progress with the aid of the atomic force microscopy (AFM) technique for biomedical and biotechnological applications, comprising both the acquisition of three-dimensional images and spectroscopic force measurements, in the following systems: first, low-density lipoprotein (LDL)-glycosaminoglycans; second, lectins-polysaccharides; third, mycobacterium leprae cellular wall and Vesicular Stomatites Virus (VSV) with fibronectin laminin, and lipidic membranes; fourth, DNA-complex; and fifth, actin, as well as the development of surface functionalizing protocols and image restoration by means of mathematical techniques.

• 出版日期2003-5