Pyran Rings Containing Polyketides from Penicillium raistrickii

作者：Ma, Li-Ying; Liu, De-Sheng; Li, De-Guo; Huang, Yu-Ling; Kang, Hui-Hui; Wang, Chun-Hua; Liu, Wei-Zhong^*

来源：Marine Drugs, 2017, 15(1): 2.

DOI：10.3390/md15010002

• Penicillium raistrickii
• alpha-pyrone
• isocoumarin
• polyketides
• saline soil-derived fungus

Five new pyran rings containing polyketides, penicipyrans A-E (1-5), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 and 5 were established by the modified Mosher's method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two ff -pyrones (1, 2), three isocoumarins (3, 4, 6), and one dihydropyran derivative (5). Among them, Compound 5 exhibited cytotoxicity against HL-60 and K562 cell lines with IC50 values of 4.4 and 8.5 mu M, respectively.

• 出版日期2017-1
• 单位滨州医学院