Antifungal properties of the anti-hypertensive drug: Aliskiren

作者：Kathwate Gunderao Hanumantrao; Karuppayil S Mohan^*

来源：Archives of Oral Biology, 2013, 58(9): 1109-1115.

DOI：10.1016/j.archoralbio.2013.02.006

• Candida albicans
• Aliskiren
• Secreted aspartic proteases
• HIV protease inhibitors

Objectives: Aliskiren, the first in a new class of orally active renin inhibitors, is licensed for the treatment of hypertension. It inhibits plasma renin activity directly, thereby reducing generation of angiotensin II. In this study, we have explored the anti-Candida properties of aliskiren.
Methods: Candida albicans was cultured in the presence or absence of aliskiren for various time periods. Subsequently, inhibition of growth, germtube formation, adhesion, early/matured biofilm development and secreted aspartic protease (SAP) activity were studied.
Results: When cultured in the presence of aliskiren, Candida showed significant reduction in the activity of aspartic proteases. Aliskiren impaired in vitro growth of C. albicans. It also affected two other virulence factors, germtube and adhesion. There is reduction in early and matured biofilm when treated with aliskiren.
Conclusions: Aliskiren could be considered as a candidate for antifungal drug development.

• 出版日期2013-9