A novel single nucleotide polymorphism in XRCC4 gene is associated with gastric cancer susceptibility in Taiwan

作者：Chiu Chang Fang; Wang Chung Hsing; Wang Cheng Li; Lin Cheng Chieh; Hsu Nan Yung; Weng Jing Ru; Bau Da Tian^*

来源：Annals of Surgical Oncology, 2008, 15(2): 514-518.

DOI：10.1245/s10434-007-9674-3

• XRCC4
• polymorphism
• gastric cancer
• carcinogenesis

Background: The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. We investigate some novel and important polymorphic variants of XRCC4, at codon 247 (rs3734091), G-1394T (rs6869366), intron 3 (rs28360071), and intron 7 (rs28360317), of their associated with gastric cancer susceptibility.
Materials and Methods: In this hospital-based case-control study, the association of XRCC4 polymorphisms with gastric cancer risk in a Taiwanese population was investigated. In total, 121 patients with gastric cancer and 121 age-matched healthy controls recruited were genotyped investigating these polymorphisms' association with gastric cancer susceptibility.
Results: We found a significant difference in the frequency of the XRCC4 G-1394T genotype, but not others, between the gastric cancer and control groups. Those who had G/T or G/G at XRCC4 G-1394T showed a 3.79-fold (95% confidence interval = 1.47-9.82) increased risk of gastric cancer compared to those with T/T. As for XRCC4 codon 247, intron 3, or intron 7, there was no difference in distribution between the gastric cancer and control groups.
Conclusions: Our findings suggest that the G allele of the XRCC4 G-1394T may contribute to gastric carcinogenesis and may be useful for gastric cancer early detection and prevention.

• 出版日期2008-2
• 单位中国医科大学