Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth

作者：Saito Makoto; Kamoda Tomohiro^*; Nishimura Kazunori; Miyazono Yayoi; Kanai Yu; Kato Yoshiaki; Iwabuchi Atsushi; Fukushima Hiroko; Hamada Hiromi; Arinami Tadao; Sumazaki Ryo; Noguchi Emiko

来源：Journal of Human Genetics, 2012, 57(2): 109-114.

DOI：10.1038/jhg.2011.134

• adiponectin
• ADIPOQ gene
• intrauterine growth
• polymorphism

To assess whether adiponectin gene (ADIPOQ) polymorphism is associated with intrauterine fetal growth and cord blood adiponectin, we investigated eight single-nucleotide polymorphisms (SNPs; rs182052, rs710445, rs16861205, rs12495941, rs1501299, rs3774261, rs2082940 and rs266729) in ADIPOQ and birth weight and cord blood adiponectin in 526 healthy neonates. We found that the neonates carrying the G allele of rs266729 had a significantly greater birth weight s.d. score than those homozygous for the C allele (CC: -0.06 +/- 0.75 versus CG: 0.20 +/- 0.64 versus GG: 0.07 +/- 0.78; P=1.65 +/- 10(-3), adjusted P=9.90 x 10(-3)). However, this difference was not significant after adjustment for cord blood adiponectin (P=0.04, adjusted P=0.26). The rs266729 SNP was strongly associated with cord blood adiponectin; neonates with rs266729 GG had the highest adiponectin (CC: 34.1 +/- 20.2 versus CG: 44.3 +/- 26.1 versus GG: 54.1 +/- 36.7 mu gml(-1), P=2.80x10(-9), adjusted P=1.68x10(-8)). This association remained after adjustment for birth weight s.d. score (P=6.63x10(-8), adjusted P=3.98x10(-7)). Our results suggest that the influence of the rs266729 SNP in ADIPOQ on birth weight may be dependent on circulating adiponectin. Journal of Human Genetics (2012) 57, 109-114; doi:10.1038/jhg.2011.134; published online 24 November 2011

• 出版日期2012-2