Novel real function based method to construct heterogeneous porous scaffolds and additive manufacturing for use in medical engineering

作者：Yang Nan^*; Tian Yanling; Zhang Dawei

来源：Medical Engineering & Physics, 2015, 37(11): 1037-1046.

DOI：10.1016/j.medengphy.2015.08.006

• Heterogeneous modelling
• Tissue engineering scaffold
• Triply periodic minimal surface
• Additive manufacturing

Heterogeneous porous scaffolds have important applications in biomedical engineering, as they can mimic the structures of natural tissues to achieve the corresponding properties. Here, we introduce a new and easy to implement real function based method for constructing complex, heterogeneous porous structures, including hybrid structures, stochastic structures, functionally gradient structures, and multi-scale structures, or their combinations (e.g., hybrid multi-scale structures). Based on micro-CT data, a femur-mimetic structure with gradient morphology was constructed using our method and fabricated using stereolithography. Results showed that our method could generate gradient porosity or gradient specific surfaces and be sufficiently flexible for use with micro-CT data and additive manufacturing (AM) techniques.

• 出版日期2015-11
• 单位天津理工大学; 天津大学