Impact of Rituximab and IPI on survival in diffuse large B cell Lymphoma patients treated at a tertiary level cancer centre in Pakistan: A single-centre experience

作者：Athar Sohail^*; Siddiqui Neelam; Rai Sulaman Raza; Muzaffar Narjis; Hameed Abdul

来源：Journal of Pakistan Medical Association, 2015, 65(2): 170-174.

• Diffuse large B cell lymphoma
• Rituximab
• Outcome
• Survival
• Chemotherapy
• Extranodal

Objective: To determine the impact of Rituximab and international prognostic index score on survival in diffuse large B-cell lymphoma patients.
Method: The retrospective study was conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from January to May 2013 and comprised record of patients with diffuse large B-cell lymphoma who were treated from 2007 to 2010. Baseline international prognostic index score, stage at presentation were noted and the records were divided into two groups A and B on the basis of the type of chemotherapy. SPSS 19 was used for statistical analysis.
Results: Of the 93 patients in the study whose records were reviewed, 54(58%) were men. Overall median age was 43 years (range: 18-76). Stages at presentation were stage-I 14(15.1%), stage-II 41 (44.1%), stage-III 20(21.5%) and stage-IV 18 (19.4%). International prognostic index risk categorisation was low risk 59(63.4%), low intermediate risk 23(24.7%), high intermediate risk 10(10.8%) and high risk 1(1.1%). There were 31(33%) patients in Group A and 62(67%) in Group B. Median follow-up was 3.9 years (range: 1.2-6.1). Overall survival at 4 years was 66.4%; for Group A 65.3% and for Group B 66.7% (p<0.4). On the basis of risk categories, overall survival was statistically significant (p<0.001) between the groups..
Conclusion: International prognostic index risk categorisation had statistically significant impact on survival. However, there was no evidence of a significant survival benefit between types of chemotherapy. Further controlled trials are needed in this regard.

• 出版日期2015-2