A high-volumn high-throughput-LC-MS therapeutic drug monitoring system

作者：Zahlsen K; Aamo T; Zweigenbaum J^*

来源：LC-GC North America, 2005, 23(4): 384-+.

Therapeutic drug monitoring is performed routinely by liquid chromatography-mass spectrometry (LC-MS) using instrumentation and methods originally developed and systematically configured for the high-volume, high-throughput analysis of drugs of abuse. An example of LC-MS monitoring of the drug clozapine and its metabolite, desmethylclozapine, is detailed along with a description of the overall system architecture, workflow, and maintenance routines that support a large-scale clinical therapeutic drug monitoring program. The relative advantages of LC-MS over immunoassay and LC-UV, the current standard techniques for therapeutic drug monitoring, are discussed in the light of these results. Historical documentation of system performance and reliability also is presented.

• 出版日期2005-4