Association of A/G Polymorphism in Intron 13 of the Monoamine Oxidase B Gene with Schizophrenia in a Spanish Population

作者：Gasso Patricia; Bernardo Miquel; Mas Sergi; Crescenti Anna; Garcia Clemente; Parellada Eduard; Lafuente Amalia^*

来源：Neuropsychobiology, 2008, 58(2): 65-70.

DOI：10.1159/000159774

• Monoamine oxidase
• Genetic polymorphism
• Schizophrenia

Background: Monoamine oxidase B (MAO-B) enzyme is involved in the oxidative metabolism of dopamine. We studied whether the A644G polymorphism in intron 13 of the MAO-B gene is a risk factor for schizophrenia. Methods: 242 subjects diagnosed with schizophrenia and related disorders and 290 hospital-based controls participated in the study. Genomic DNA was isolated from whole blood and genotyped with the allele-specific oligonucleotide polymerase chain reaction method. Results: This polymorphism was studied by diagnosis subgroups and the G allele was identified as a risk factor for developing schizophrenia (p = 0.006). When we performed a sex-specific analysis, the G allele was only a risk factor for developing schizophrenia in women (p = 0.01). Although the frequency of the G allele is higher in male patients than in male controls, no statistically significant association with schizophrenia was found. Conclusion: Our results support the involvement of the MAO-B gene in schizophrenia, particularly in women.

• 出版日期2008