科研之友
微信
新浪微博
Facebook
分享链接
摘要
Two series of spiro-oxindole dihydroquinazolinone derivatives have been designed and synthesized using a catalytic amount of nano cerium oxide with excellent product yields by a convenient one-pot process. The synthesized compounds were evaluated for their in vitro antibacterial activity, and compounds 1i-1p showed considerable antibacterial activities to Escherichia coli. Molecular docking of E. coli Biotin Carboxylase (EcBC) enzyme was also performed in order to predict the interactions of the synthesized compounds.
- 出版日期2016-2-18
- 单位陕西科技大学
