A case with coincidental diagnosis of primary central nervous system lymphoma and lymph node sarcoidosis

作者：Greiner Eva J^*; Muegge Lars Olof; Romeike Bernd F M; Topalidis Theodoros; Theis Bernhard; Ragoschke Schumm Andreas; Witte Otto W; Guenther Albrecht

来源：Journal of Neuro-Oncology, 2010, 99(1): 129-134.

DOI：10.1007/s11060-009-0101-4

• Primary central nervous system lymphoma
• Non-Hodgkin's lymphoma
• Neurosarcoidosis

Primary central nervous system lymphoma (PCNSL) is rare. Clinical and histological differential diagnosis of systemic lymphoma and sarcoidosis continues to be a challenge. The first case report in the German and English literature of PCNSL and synchronous sarcoidosis is presented. Synchronous mediastinal lymphadenopathy suggestive of non-Hodgkin's lymphoma (NHL) or sarcoidosis was noted. Both conditions require alternative therapeutic and prognostic considerations to PCNSL. A regime of intrathecal and adjuvant systemic chemotherapy led to transient clinical improvement prior to the patient's demise through overwhelming sepsis and multiorgan failure. Post mortem findings confirmed synchronous PCNSL with mediastinal lymph node sarcoidosis.

• 出版日期2010-8