Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia

作者：Lin Jessica T^*; Ubalee Ratawan; Lon Chanthap; Balasubramanian Sujata; Kuntawunginn Worachet; Rahman Rifat; Saingam Piya****; Thay Kheang Heng; Dav Vy; San Savoeun; Nuom Sarath; Burkly Hana; Chanarat Nitima; Ponsa Chanudom; Levitz Lauren; Parobek Christian; Chuor Char Meng; Somethy Sok; Spring Michele; Lanteri Charlotte; Gosi Panita; Meshnick Steven R; Saunders David L

来源：Journal of Infectious Diseases, 2016, 213(9): 1491-1494.

DOI：10.1093/infdis/jiv599

• gametocyte
• membrane feeding
• infectious reservoir
• malaria transmission
• Plasmodium falciparum
• submicroscopic
• Anopheles dirus

Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable gametocytes still infect mosquitoes. To see whether the same is true in Southeast Asia, we determined the infectiousness of 119 falciparum-infected Cambodian adults to Anopheles dirus mosquitoes by membrane feeding. Just 5.9% of subjects infected mosquitoes. The 8.4% of patients with smear-detectable gametocytes were >20 times more likely to infect mosquitoes than those without and were the source of 96% of all mosquito infections. In low-transmission settings, targeting transmission-blocking interventions to those with microscopic gametocytemia may have an outsized effect on malaria control and elimination.

• 出版日期2016-5-1
• 单位河北医科大学