A general rhodium-catalyzed cross-coupling reaction of thiols with aryl iodides

作者：Lai, Chih-Shin; Kao, Hsin-Lun; Wang, Yan-Jhang; Lee, Chin-Fa^*

来源：Tetrahedron Letters, 2012, 53(33): 4365-4367.

DOI：10.1016/j.tetlet.2012.06.054

• Rhodium
• Cross-coupling
• Thiol
• Aryl iodide
• Phosphine

The general procedure for the rhodium-catalyzed cross-coupling of thiols with aryl iodides is described. The catalytic system consists of 5 mol % of [RhCl(cod)](2) and 10 mol % of PPh3 as a ligand. A variety of aryl iodides reacted with thiols, giving aryl thioethers in good to excellent yields. It is important to note that the deactivated aryl iodides such as 4-iodoanisole is worked smoothly to provide the corresponding aryl thioethers in excellent yields. Functional groups such as free-amines, chloro, are all tolerated under the employed reaction conditions.

• 出版日期2012-8-15